This study investigated the influence of Open and Distance Learning (ODL) on the teaching and learning process at Gretsa University, Kiambu County, Kenya. The study evaluated content coverage, skill development, the impact of blended learning, practical exposure, and learner-lecturer interactions, using a descriptive survey design with data collected from 70 participants using a simple random sampling technique and online surveys . Findings indicated that ODL enhanced timely syllabus coverage, equipped learners with essential skills, promoted flexibility and collaborative learning, and ensured access to quality education. However, challenges such as limited interaction, outdated content, and insufficient practical exposure were identified. Recommendations included designing engaging and interactive ODL programs, providing recent examples to reflect current trends, and establishing effective communication channels. Further research was suggested to explore ODL's influence in other institutions to broaden understanding and address challenges, ultimately fostering a positive attitude toward its adoption and implementation.